Application of Physiologically Based Pharmacokinetic Modeling to Predict the Effect of Renal Impairment on the Pharmacokinetics of Olanzapine and Samidorphan Given in Combination.

Lei SunLisa von MoltkeKaren Rowland Yeo

Published in: Clinical pharmacokinetics (2020)

Physiologically based pharmacokinetic modeling extended the findings from a clinical study in severe renal impairment to other untested clinical scenarios; these data could be of interest to clinicians treating patients with renal impairment.

Keyphrases

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clinical trial
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machine learning
drug induced