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Autoimmune disease is associated with a lower risk of progression in monoclonal gammopathy of undetermined significance.

Theodóra Rún BaldursdóttirÞorvarður Jón LöveGauti Kjartan GíslasonMagnus BjörkholmUlf-Henrik MellqvistSigrun Helga LundCecilie Hveding BlimarkIngemar TuressonMalin HultcrantzOla LandgrenSigurður Yngvi Kristinsson
Published in: European journal of haematology (2020)
In this large population-based study, a history of autoimmune disease was associated with a reduced risk of progression from MGUS to MM/other LPs. Potential underlying reason is that MGUS caused by chronic antigen stimulation is biologically less likely to undergo the genetic events that trigger progression. Our results may have implications in clinical counseling for patients with MGUS and underlying autoimmune disease.
Keyphrases
  • multiple sclerosis
  • drug induced
  • gene expression
  • risk assessment