PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation.

Maria B Campaña Madison R PerkinsMaxwell C McCabeAndrew NeumannEric D Larson Katherine A Fantauzzo

Published in: bioRxiv : the preprint server for biology (2023)

PDGFRα/β heterodimer binding to MYO1D contributes to rapid internalization of the dimerized receptors, thereby negatively affecting downstream ERK1/2 signaling and cellular proliferation.

Keyphrases

signaling pathway
pi k akt
cell proliferation