Rhenium(i) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease.
Chung Ying ChanAsif NoorCatriona A McLeanPaul S DonnellyPeter J BarnardPublished in: Chemical communications (Cambridge, England) (2018)
A series of [Re(i)L(CO)3]+ complexes (where L is a bifunctional bis(NHC)-amine ligand) that are analogues of potential Tc-99m diagnostic imaging agents for Alzheimer's disease have been synthesised. One of the complexes bound to amyloid plaques in human frontal cortex brain tissue from subjects with Alzheimer's disease.
Keyphrases
- cognitive decline
- functional connectivity
- endothelial cells
- high resolution
- resting state
- multiple sclerosis
- white matter
- mass spectrometry
- molecular docking
- mild cognitive impairment
- blood brain barrier
- brain injury
- climate change
- risk assessment
- subarachnoid hemorrhage
- fluorescence imaging
- cerebral ischemia
- structure activity relationship