Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability.

Zhi-Qiang MaYing-Tong FengKai GuoDong LiuChang-Jian ShaoMing-Hong PanYi-Meng ZhangYu-Xi ZhangDi LuDi HuangFan ZhangJin-Liang WangBo YangJing HanXiao-Long YanYi Hu

Published in: Military Medical Research (2022)

Our findings elucidate that melatonin mitigates the HDAC7/β-catenin/c-Myc positive feedback loop and inhibits the USP10-maintained HDAC7 protein stability thus suppressing ESCC cell growth, and provides the reference for identifying biomarkers and therapeutic targets for ESCC.

Keyphrases

histone deacetylase
epithelial mesenchymal transition
signaling pathway
cell proliferation
transcription factor
protein protein
amino acid
binding protein
radiation therapy
radiation induced