Automated synthesis of 18F radiolabelled indole containing Oncrasin-like molecules; a comparison of iodonium salts and boronic ester chemistry.

Alexander Franklin McDonaldYit Wooi GohJonathan M White Andrew Mark ScottUwe Ackermann

Published in: EJNMMI radiopharmacy and chemistry (2020)

The successful synthesis of these tracers has been undertaken utilizing boronic ester radio-fluorination methods and will allow for investigation of Oncrasin based molecules as potential diagnostics for cancers expressing mutant KRAS protein.

Keyphrases

wild type
deep learning
high throughput
amino acid
protein protein
human health
risk assessment
climate change