Murine model for chronic rhinosinusitis: an interventional study.

Amr F HamourJohn J W LeeEwa WasilewskiEric MonteiroJohn M LeeAllan VescanLakshmi P Kotra

Published in: Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale (2023)

This murine model induced substantial local eosinophilic inflammation within sinonasal mucosa, that was reversible with mometasone. This model may be used to evaluate the efficacy of therapeutics designed to target CRS.

Keyphrases

chronic rhinosinusitis
oxidative stress
high glucose
small molecule
endothelial cells
stress induced