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Mitochondrial ALDH2 improves ß-cell survival and function against doxorubicin-induced apoptosis by targeting CK2 signaling.

Udayakumar KarunakaranEun Yeong HaSuma ElumalaiKyu Chang WonJun Sung Moon
Published in: Journal of diabetes investigation (2024)
Mitochondrial ALDH2 activation could inhibit the progression of doxorubicin induced pancreatic β-cell dysfunction by inhibiting the acid sphingomyelinase induction of ceramide, by regulating the activation of CK2 signaling. Our research lays the foundation of ALDH2 activation as a therapeutic target for the precise treatment of chemotherapy drug induced β-cell dysfunction.
Keyphrases
  • drug induced
  • oxidative stress
  • induced apoptosis
  • liver injury
  • single cell
  • diabetic rats
  • signaling pathway
  • drug delivery
  • cell therapy
  • squamous cell carcinoma
  • stem cells
  • high glucose
  • electronic health record