Therapeutic effects of anti-GM2 CAR-T cells expressing IL-7 and CCL19 for GM2-positive solid cancer in xenograft model.

Takahiro SasakiYukimi SakodaKeishi AdachiYoshihiro TokunagaKoji Tamada

Published in: Cancer medicine (2023)

Our study revealed the promising therapeutic efficacy of anti-GM2 IL-7/CCL19-producing human CAR-T cells with an enhanced safety for clinical application in the treatment of patients with GM2-positive solid cancers.

Keyphrases

induced apoptosis
cell cycle arrest
endothelial cells
papillary thyroid
single cell
cell proliferation
combination therapy
childhood cancer