Pathological Lymph Node Regression After Neoadjuvant Chemotherapy Predicts Recurrence and Survival in Esophageal Adenocarcinoma: A Multicenter Study in the United Kingdom.
Jonathan L MooreMichael GreenAida SantaolallaHarriet DeereRichard P T EvansMona ElshafieAnita LaveryDamian T McManusAndrew J McGuiganRosalie DouglasJoanne HorneRobert C WalkerHira MirMonica TerlizzoSivesh Kathir KamarajahMieke Van HemelrijckNick MaiseyAilsa Sita-LumsdenSarah NganMark KellyCara R BakerSacheen KumarJesper LagergrenWilliam H AllumJames A GossageEwen Alexander GriffithsHeike I GrabschRichard C TurkingtonTimothy J UnderwoodElizabeth C SmythRebecca C FitzgeraldDavid CunninghamAndrew R DaviesPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
Pathological LN regression after neoadjuvant chemotherapy was a strong prognostic factor and provides important information beyond pathological TNM staging and primary tumor regression grading. LN regression should be included as standard in the pathological reporting of esophagectomy specimens.