IGF-1C domain-modified hydrogel enhances therapeutic potential of mesenchymal stem cells for hindlimb ischemia.

Nianhuan ZhaoZhiwei YueJian CuiYong YaoXianghe SongBangping CuiXin QiZhibo HanZhong-Chao HanZhikun GuoZuo-Xiang HeZongjin Li

Published in: Stem cell research & therapy (2019)

Taken together, IGF-1Cs provides a conducive niche for hP-MSCs to exert pro-mitogenic, anti-apoptotic, and pro-angiogenic effects, as well as to inhibit fibrosis. Thus, the incorporation of functional peptide into bioscaffolds represents a safe and feasible approach to augment the therapeutic efficacy of stem cells.

Keyphrases

mesenchymal stem cells
stem cells
anti inflammatory
umbilical cord
pi k akt
cell therapy
binding protein
cell death
bone marrow
growth hormone
drug delivery
hyaluronic acid