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Treatment of the most difficult-to-cure hepatitis C virus-infected population with sofosbuvir / velpatasvir.

Robert FlisiakDorota Zarębska-MichalukHanna BerakMagdalena Tudrujek-ZdunekBeata LorencKrystyna DobrowolskaJustyna Janocha-LitwinWłodzimierz MazurAnna Parfieniuk-KowerdaJerzy Jaroszewicz
Published in: Polish archives of internal medicine (2024)
In a large population of SOF/VEL‑treated HCV‑infected patients, we showed relatively low effectiveness of the regimen in treatment‑experienced men with cirrhosis and obesity, infected with GT3. Triple therapy should be considered when initiating the treatment of HCV infections in this group, which, however, needs to be confirmed in further studies. Previous studies were conducted in less demanding populations, because they did not take into account sex and BMI, which significantly affect the treatment effectiveness.
Keyphrases
  • hepatitis c virus
  • human immunodeficiency virus
  • stem cells
  • insulin resistance
  • combination therapy
  • skeletal muscle
  • bone marrow
  • replacement therapy
  • weight gain
  • hiv infected
  • case control