Strategic use of levofolinic acid for methotrexate-induced side effects in juvenile idiopathic arthritis: a prospective observational study.

Giorgia MartiniAlessandra MeneghelMichele FastiggiFilippo Dell'ApaFabio VittadelloFrancesco Zulian

Published in: Pediatric rheumatology online journal (2023)

LVF given 48 h before MTX significantly reduced gastrointestinal side effects and did not reduce drug's efficacy. Our results suggest that this strategy may improve compliance and quality of life in patients with JIA and other rheumatic diseases treated with MTX.

Keyphrases

juvenile idiopathic arthritis
disease activity
drug induced
high glucose
diabetic rats
rheumatoid arthritis
emergency department
adverse drug
low dose
newly diagnosed