miR-214-3p-Sufu-GLI1 is a novel regulatory axis controlling inflammatory smooth muscle cell differentiation from stem cells and neointimal hyperplasia.

Shiping HeFeng YangMei YangWeiwei AnEithne Margaret MaguireQishan ChenRui XiaoWei WuLi ZhangWen WangQingzhong Xiao

Published in: Stem cell research & therapy (2020)

We present a previously unexplored role for miR-214-3p in iSMC differentiation and neointima iSMC hyperplasia and provide new insights into the therapeutic effects of miR-214-3p in vascular disease.

Keyphrases

smooth muscle
stem cells
oxidative stress
transcription factor
cell therapy
bone marrow