A modified anthrax toxin-based enzyme-linked immunospot assay reveals robust T cell responses in symptomatic and asymptomatic Ebola virus exposed individuals.

Bobby Brooke HerreraDonald J HamelPhilip OshunRolake AkinsolaAlani Sulaimon AkanmuCharlotte A ChangPhilomena EromonOnikepe FolarinTolulope A KayodeChristian T HappiYichen LuFolasade OgunsolaPhyllis J Kanki

Published in: PLoS neglected tropical diseases (2018)

Our data provide further evidence of EBOV exposure in individuals without EVD-like illness and, for the first time, demonstrate that these individuals have T cell responses that are stronger in magnitude compared to severe cases. These findings suggest that T cell immunity may protect against severe EVD, which has important implications for vaccine development.

Keyphrases

early onset
escherichia coli
high throughput
electronic health record
big data
machine learning
single cell
artificial intelligence