Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression.
Fengguang MaYuxiao LiuZhimin HuYaqian XueZhengshuai LiuGenxiang CaiWeitong SuZengpeng ZhengXia FangXi YanDong DingXiaoyang SunYang JiangShuang WeiWenjing LiJiuxiang ZhaoHaibing ZhangHong LiDong-Guang XiaoCui-Ying ZhangHao YingJun QinXin GaoXiaozhen DaiWenguang FuYong XuYu LiAoyuan CuiPublished in: Hepatology (Baltimore, Md.) (2023)
Osteopontin signaling by CREBZF represents a previously unrecognized intrahepatic mechanism that triggers liver fibrosis and contributes to the severity of NASH.