SERPINB11 variant-related liver injury in STEC-HUS: case reports and literature review.

Nazlı Umman Mey Talip Cigdem Arikan Cansu Altuntaş Biray Ertürk Hasan Dursun

Published in: Pediatric nephrology (Berlin, Germany) (2022)

Our patients presented with kidney impairment and liver malfunction. Hepatic involvement in STEC-HUS may result from ischemia, hemolysis, and endothelial damage in the hepatic vessels. Liver injury in STEC-HUS cases may be associated with the homozygous SERPINB11 gene c.268G > T (p.Glu90Ter) variant.

Keyphrases

liver injury
drug induced
end stage renal disease
case report
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
oxidative stress
endothelial cells
copy number
patient reported outcomes