Single- and Multi-Arm Gadolinium MRI Contrast Agents for Targeted Imaging of Glioblastoma.

Rameshwar Patil Anna GalstyanZachary B GrodzinskiEkaterina S Shatalova Shawn Wagner Liron Limor IsraelHui DingKeith L BlackJulia Y LjubimovaEggehard Holler

Published in: International journal of nanomedicine (2020)

The novel targeted NCAs with star-PEG features displayed improved relaxivity and greater contrast compared with commercial MultiHance contrast agent. The enhancement by mini-NCAs showed clearance of tumor contrast after 3 hours providing a suitable time window for tumor diagnosis in clinics. The technology provides a great tool with the promise of differential MRI diagnosis of brain tumors.

Keyphrases

contrast enhanced
magnetic resonance
magnetic resonance imaging
computed tomography
diffusion weighted imaging
cancer therapy
primary care
high resolution
big data
mass spectrometry