Long-term follow-up including extensive complement analysis of a pediatric C3 glomerulopathy cohort.
Marloes A H M MichelsKioa Lente WijnsmaRoel A J KurversDineke WestraMichiel F SchreuderJoanna A E van WijkAntonia H M BoutsValentina GracchiFlore A P T EngelsMandy G Keijzer-VeenEiske M DorresteijnElena B VolokhinaLambertus P W J van den HeuvelNicole C A J van de KarPublished in: Pediatric nephrology (Berlin, Germany) (2021)
We extensively described clinical and laboratory findings including complement features of an exclusively pediatric C3G cohort. Outcome was relatively benign, persistent low C3 correlated with C3NeF presence, and C3GN was associated with higher sC5b-9 and lower properdin levels. Prospective studies are needed to further elucidate the pathogenic mechanisms underlying C3G and guide personalized medicine with complement therapeutics.
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