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The IL-1β-p65 axis stimulates quiescent odontogenic epithelial cell rests via TGF-β signalling to promote cell proliferation of the lining epithelia in radicular cysts: A laboratory investigation.

Ryoko NaganoYusuke NakakoShinsuke FujiiShintaro KawanoHidefumi MaedaTamotsu Kiyoshima
Published in: International endodontic journal (2024)
These results suggest that IL-1β-p65 signalling promotes odontogenic epithelial cell proliferation through suppressing TGF-β-Smad2 signalling, which would be involved in the pathogenesis of radicular cysts.
Keyphrases
  • cell proliferation
  • transforming growth factor
  • cell cycle
  • epithelial mesenchymal transition
  • pi k akt
  • signaling pathway