A reduced pancreatic polypeptide response is associated with new onset pancreatogenic diabetes versus type 2 diabetes.
Phil A HartYogish C KudvaDhiraj YadavDana K AndersenYisheng LiFrederico G S ToledoFuchenchu WangMelena D BellinDavid BradleyRandall E BrandKenneth CusiWilliam FisherKieren MatherWalter G ParkZeb SaeedRobert V ConsidineSarah C GrahamJo Ann RinaudoJose SerranoMark O GoodarziPublished in: The Journal of clinical endocrinology and metabolism (2022)
Fasting PP concentrations and the response to meal stimulation are reduced in new onset DM associated with PDAC or CP compared to T2DM. These findings support further investigations into the use of PP concentrations to characterize pancreatogenic DM, and to understand the pathophysiological role in exocrine pancreatic diseases. (NCT03460769).