Formation of gadolinium-ferritin from clinical magnetic resonance contrast agents.
Jitka NeburkovaAaron Michael RulsehShery L Y ChangHelena RaabovaJana VejpravováMartin DračínskýJán TarábekJan KotekMohan PinglePavel MajerJosef VymazalPetr CiglerPublished in: Nanoscale advances (2020)
Gadolinium deposition in the brain following administration of gadolinium-based contrast agents (GBCAs) has led to health concerns. We show that some clinical GBCAs form Gd 3+ -ferritin nanoparticles at (sub)nanomolar concentrations of Gd 3+ under physiological conditions. We describe their structure at atomic resolution and discuss potential relevance for clinical MRI.