A versatile contribution of both aminopeptidases N and ABC transporters to Bt Cry1Ac toxicity in the diamondback moth.
Dan SunLiuhong ZhuLe GuoShaoli WangQingjun WuNeil CrickmoreXuguo ZhouAlejandra BravoMario SoberónZhaojiang GuoYou-Jun ZhangPublished in: BMC biology (2022)
Our results provide direct evidence that APN1 and APN3a are important for Cry1Ac toxicity. They support our overarching hypothesis of a versatile mode of action of Bt toxins, which can compensate for the absence of individual receptors, and are consistent with an interplay among diverse midgut receptors in the toxins' mechanism of action in a super pest.
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