DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance.

Flora D'AnnaLaurien Van DyckJieyi XiongHui ZhaoRebecca V BerrensJunbin QianPawel Bieniasz-KrzywiecVikas ChandraLuc SchoonjansJason MatthewsJulie De SmedtLiesbeth MinnoyeRicardo AmorimSepideh KhorasanizadehQian YuLiyun ZhaoMarie De BorreSavvas N SavvidesM Celeste SimonPeter CarmelietWolf ReikFraydoon RastinejadMassimiliano MazzoneBernard ThienpontDiether Lambrechts

Published in: Genome biology (2020)

Our data elucidate the mechanism underlying cell-type-specific responses to hypoxia and suggest DNA methylation and hypoxia to underlie tumor immunotolerance.

Keyphrases

dna methylation
endothelial cells
genome wide
gene expression
transcription factor
dna binding
big data
machine learning
binding protein