Pregnancy, perinatal and childhood outcomes in women with and without polycystic ovary syndrome and metformin during pregnancy: a nationwide population-based study.

Romina FornesJohanna SiminMinh Hanh NguyenGonzalo CruzNicolás CrisostoMaartje van der SchaafLars EngstrandNele Brusselaers

Published in: Reproductive biology and endocrinology : RB&E (2022)

PCOS was associated with increased risks of adverse pregnancy and perinatal outcomes and childhood obesity. Metformin appears to reduce these risks in mothers with polycystic ovary syndrome and their children; but may increase the risk of childhood-obesity in children form women without PCOS.

Keyphrases

polycystic ovary syndrome
insulin resistance
young adults
pregnant women
preterm birth
pregnancy outcomes
human health
adipose tissue
type diabetes
skeletal muscle
glycemic control
adverse drug
drug induced
electronic health record