Trimetallic Nitride Endohedral Fullerenes Carboxyl-Gd3N@C80: A New Theranostic Agent for Combating Oxidative Stress and Resolving Inflammation.
Tinghui LiLi XiaoJiezuan YangMengmeng DingZhiguo ZhouLeslie LaConteLi JinHarry C DornXudong LiPublished in: ACS applied materials & interfaces (2017)
Antioxidative and anti-inflammatory effects of trimetallic nitride endohedral fullerenes carboxyl-Gd3N@C80, a newly developed magnetic resonance imaging (MRI) contrast agent, were investigated. All hydrochalarone and carboxyl-functionalized fullerenes showed effective radical (hydroxyl and superoxide anion) scavenging, whereas the carboxyl-Gd3N@C80 more efficiently attenuated lipopolysaccharide (LPS) induced oxidative stress in macrophages. Carboxyl-Gd3N@C80 also suppressed LPS-elicited mRNA expression of pro-inflammatory inducible nitric oxide synthase and tumor necrosis factor-alpha, and upregulated antioxidative enzyme axis Nrf2 and heme oxygenase-1, possibly via ERK but not AKT signaling pathways. Therefore, carboxyl-Gd3N@C80 held a great promise in becoming a novel theranostic nanoplatform for simultaneously deliver MRI contrast and therapeutic functions to inflammation-related diseases.
Keyphrases
- anti inflammatory
- oxidative stress
- magnetic resonance imaging
- contrast enhanced
- signaling pathway
- nitric oxide synthase
- photodynamic therapy
- inflammatory response
- magnetic resonance
- quantum dots
- nitric oxide
- hydrogen peroxide
- dna damage
- cell proliferation
- induced apoptosis
- diffusion weighted imaging
- immune response
- epithelial mesenchymal transition
- ionic liquid
- fluorescence imaging
- lps induced
- endoplasmic reticulum stress
- drug induced
- molecularly imprinted
- visible light
- big data
- high speed