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Dissecting the phenotypic heterogeneity in sensory features in autism spectrum disorder: a factor mixture modelling approach.

Julian TillmannM UljarevicD CrawleyG DumasE LothD MurphyJ BuitelaarT Charmannull null
Published in: Molecular autism (2020)
Sensory features can be best described by three homogeneous sensory subgroups that differ in sensory severity gradients along seven continuous factor scores. Identified sensory subgroups were further differentiated by the severity of core and co-occurring symptoms, and level of adaptive functioning, providing novel evidence on the associated clinical correlates of sensory subgroups. These sensory subgroups provide a platform to further interrogate the neurobiological and genetic correlates of altered sensory processing in ASD.
Keyphrases
  • autism spectrum disorder
  • attention deficit hyperactivity disorder
  • high throughput
  • working memory
  • sleep quality