Genomic, microbial and environmental standardization in animal experimentation limiting immunological discovery.

Josue EnriquezBrianyell Mc Daniel MimsScott TrastiKathryn L FurrMatthew B Grisham

Published in: BMC immunology (2020)

Exposure of genetically diverse mice to a spectrum of environmentally-relevant microorganisms at housing temperatures that approximate their thermo-neutral zone may improve the chances of identifying new and more potent therapeutics to treat infectious and inflammatory diseases.

Keyphrases

small molecule
microbial community
high fat diet induced
oxidative stress
copy number
high throughput
mental illness
human health
anti inflammatory
type diabetes
wild type
insulin resistance
metabolic syndrome
dna methylation
skeletal muscle
genome wide
climate change
single cell