Bone marrow-derived mesenchymal stem cells improve post-ischemia neurological function in rats via the PI3K/AKT/GSK-3β/CRMP-2 pathway.
Xiaohui LinHongbin ChenManli ChenTing LiYongxing LaiLongzai LinPeiqiang LinJi LiuYixian ZhangRonghua ChenHouwei DuXinhong JiangXin-Hong JiangPublished in: Molecular and cellular biochemistry (2021)
These data suggest that transplantation of BMSCs could promote axon growth and neurological deficit recovery after MCAO, which was associated with activation of PI3K/AKT /GSK-3β/CRMP-2 signaling pathway.
Keyphrases
- pi k akt
- signaling pathway
- bone marrow
- cell cycle arrest
- cell proliferation
- mesenchymal stem cells
- induced apoptosis
- electronic health record
- epithelial mesenchymal transition
- cerebral ischemia
- big data
- cell therapy
- subarachnoid hemorrhage
- deep learning
- optical coherence tomography
- blood brain barrier
- artificial intelligence