A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program.
Sridharan RaghavenJie HuangCatherine TcheandjieuJennifer E HuffmanElizabeth M LitkowskiChang LiuYuk-Lam Anne HoHaley Hunter-ZinckHongyu ZhaoEirini MarouliKari E Northnull nullEthan LangeLeslie A LangeBenjamin F VoightJ Michael GazianoSaiju PyarajanElizabeth R HauserPhilip S TsaoPeter W F WilsonKyong-Mi ChangKelly ChoChristopher J O'DonnellYan V SunThemistocles L AssimesPublished in: PLoS genetics (2022)
We conclude that height may be an unrecognized but biologically plausible risk factor for several common conditions in adults. However, more studies are needed to reliably exclude horizontal pleiotropy as a driving force behind at least some of the MR associations observed in this study.
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