Neutrophil extracellular traps mediate bone erosion in rheumatoid arthritis by enhancing RANKL-induced osteoclastogenesis.
Ayda Henriques SchneiderThaise Mayumi TairaGabriel Azevedo PúblioDouglas da Silva PradoPaula Barbim Donate YabutaJéssica Cristina Dos SantosCaio Cavalcante MachadoFlávio Falcão Lima de SouzaLucas Gabriel Rodrigues VenturiniRenê Donizeti Ribeiro de OliveiraThiago Mattar CunhaJosé Carlos Alves FilhoPaulo Louzada-JúniorTarcília Aparecida da SilvaSandra Yasuyo Fukada AlvesFernando de Queiroz CunhaPublished in: British journal of pharmacology (2023)
Inhibiting NETs could be an alternative strategy to reduce bone erosion in arthritis patients.
Keyphrases
- rheumatoid arthritis
- bone loss
- end stage renal disease
- bone mineral density
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- signaling pathway
- disease activity
- diabetic rats
- oxidative stress
- drug induced
- patient reported outcomes
- ankylosing spondylitis
- interstitial lung disease
- lps induced
- inflammatory response
- nuclear factor
- idiopathic pulmonary fibrosis