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Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression.

Weifen LiTahir AliChengyou ZhengZizhen LiuKaiwu HeFawad Ali ShahQingguo RenShafiq Ur RahmanNingning LiZhi-Jian YuShupeng Li
Published in: Journal of neuroinflammation (2021)
Our results showed that the antidepressant effects of fluoxetine may involve HDAC1-eEF2 related neuroinflammation and synaptogenesis.
Keyphrases
  • lps induced
  • mouse model
  • inflammatory response
  • histone deacetylase
  • major depressive disorder
  • depressive symptoms
  • lipopolysaccharide induced
  • sleep quality
  • protein kinase
  • physical activity