Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia.

Yui UmeharaToki KageyamaAoi SonYu KimuraTeruyuki Kondo Kazuhito Tanabe

Published in: RSC advances (2019)

Tumor-selective accumulation of gold nanorods (GNR) has been demonstrated for visualization of tumor hypoxia by photoacoustic imaging. We prepared GNRs with hypoxia-targeting nitroimidazole units (G-NI) on their surface. Biological experiments revealed that G-NI produced a strong photoacoustic signal in hypoxic tumor cells and tissues.

Keyphrases

fluorescence imaging
high resolution
endothelial cells
gene expression
single cell
photodynamic therapy
drug delivery
mass spectrometry
simultaneous determination