Assessing the Global Impact on the Mouse Kidney After Traumatic Brain Injury: A Transcriptomic Study.

Wei-Hung ChanYu-Juei HsuChiao-Pei ChengKuan-Nien ChouChin-Li ChenShih-Ming HuangWei-Chih KanYi-Lin Chiu

Published in: Journal of inflammation research (2022)

This study is the first to reveal the effects of brain trauma on the kidney. TBI may affect the expression of mitochondria function-related gene sets in renal cells by increasing lactate. It may also affect renal mesangial cells by inducing increased infiltration of immune cells through mechanisms related to complement system activation or autoimmune antibodies.

Keyphrases

induced apoptosis
cell cycle arrest
traumatic brain injury
genome wide
cell death
single cell
multiple sclerosis
signaling pathway
gene expression
oxidative stress
dna methylation
copy number
rna seq
endothelial cells
drug induced
high glucose
genome wide identification