Analysis of maternal Fc gamma receptor IIIb isoantibodies using immunomagnetic negative selected neutrophils.

Juliana Oliveira MartinsElyse MoritzSamira Ali AbbasBehnaz BayatMelca Maria Oliveira BarrosRenato de MarcoRenata Fantini MachadoJosé Orlando Bordin

Published in: Vox sanguinis (2024)

Two cases of maternal anti-FcγRIIIb isoantibodies, unrelated to NAIN, were identified. Although neutropenia has not been described in these cases, we emphasize the importance of identifying asymptomatic cases with the potential for severe neutropenia. Additionally, IMNS is introduced as a rapid, high-yield, high-purity neutrophil isolation technique, beneficial for serological assays detecting anti-HNA antibodies.

Keyphrases

birth weight
pregnancy outcomes
chemotherapy induced
early onset
physical activity
body mass index
gestational age
binding protein
sensitive detection