Proteotranscriptomics of ocular adnexal B-cell lymphoma reveals an oncogenic role of alternative splicing and identifies a diagnostic marker.

Jiahao ShiTianyu ZhuHuimin LinZhen LiuMin ZhouZiyao YuXiaowen ZhouXin SongYefei WangRenbing JiaXianqun FanYixiong Zhou

Published in: Journal of experimental & clinical cancer research : CR (2022)

These results provide an integrated gene expression profiling and demonstrate that high global protein-mRNA concordance is a prognosis-related molecular characteristic of OABL. We portray the alternative splicing events landscape of OABL, and reveal the oncogenic role of ADAR. We identified strong nuclear staining of DNAJC9 as a promising pathology diagnostic biomarker for extranodal marginal zone lymphomas.

Keyphrases

genome wide
dna methylation
transcription factor
copy number
genome wide identification
single cell
diffuse large b cell lymphoma
binding protein
protein protein
gene expression
single molecule
small molecule
amino acid
optical coherence tomography
drug induced
flow cytometry