Proteotranscriptomics of ocular adnexal B-cell lymphoma reveals an oncogenic role of alternative splicing and identifies a diagnostic marker.
Jiahao ShiTianyu ZhuHuimin LinZhen LiuMin ZhouZiyao YuXiaowen ZhouXin SongYefei WangRenbing JiaXianqun FanYixiong ZhouPublished in: Journal of experimental & clinical cancer research : CR (2022)
These results provide an integrated gene expression profiling and demonstrate that high global protein-mRNA concordance is a prognosis-related molecular characteristic of OABL. We portray the alternative splicing events landscape of OABL, and reveal the oncogenic role of ADAR. We identified strong nuclear staining of DNAJC9 as a promising pathology diagnostic biomarker for extranodal marginal zone lymphomas.