Comparison of an angiotensin-I-converting enzyme inhibitory peptide from tilapia (Oreochromis niloticus) with captopril: inhibition kinetics, in vivo effect, simulated gastrointestinal digestion and a molecular docking study.

Jiali ChenBomi RyuYuanYuan ZhangPeng LiangChengyong LiChunxia ZhouPing YangPengzhi HongZhong-Ji Qian

Published in: Journal of the science of food and agriculture (2019)

LSGYGP, with an IC50 value of 2.577 μmol L-1 , has an antihypertensive effect in spontaneously hypertensive rats. Through comparison with captopril, this study revealed that LSGYGP may be a potential food-derived ACE inhibitory peptide and could act as a functional food ingredient to prevent hypertension. © 2019 Society of Chemical Industry.

Keyphrases

molecular docking
blood pressure
angiotensin ii
molecular dynamics simulations
angiotensin converting enzyme
human health
risk assessment
climate change
single cell
hypertensive patients