Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile.
Adrian H HealdSusan MartinHelene FachimHarry D GreenKatherine G YoungNagaraj MalipatilKirk SiddalsGabriela CortesJessica TyrrellAndrew R WoodRobin N BeaumontTimothy M FraylingRachelle DonnRam Prakash NarayananWilliam OllierMartin GibsonHanieh YaghootkarPublished in: Diabetic medicine : a journal of the British Diabetic Association (2021)
In individuals with type 2 diabetes, having more 'favourable adiposity' alleles is associated with a marginally better lipid profile long-term and having lower odds of requiring lipid-lowering or anti-hypertensive medication in spite of relatively higher adiposity.