Arabinofuranose-derived positron-emission tomography radiotracers for detection of pathogenic microorganisms.
Mausam KalitaMatthew F L ParkerJustin M LuuMegan N StewartJoseph E BlechaHenry F VanBrocklinMichael J EvansRobert R FlavellOren S RosenbergMichael A OhligerDavid M WilsonPublished in: Journal of labelled compounds & radiopharmaceuticals (2020)
Arabinofuranose-derived 18 F PET radiotracers can be synthesized with high radiochemical purity. Our study showed absence of bacterial accumulation for 5-substitued analogs, a finding that may have mechanistic implications for related tracers. Both d-2-18 F-AF and l-2-18 F-AF showed sensitivity to most gram-negative and gram-positive organisms. Future in vivo studies will evaluate the diagnostic accuracy of these radiotracers in animal models of infection.