Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer's disease.
Artem ZatcepinJohannes GnörichBoris-Stephan RauchmannLaura M BartosStephan WagnerNicolai FranzmeierMaura MalpettiXianyuan XiangYuan ShiSamira ParhizkarMaximilian GroschKarin Wind-MarkSebastian T KunteLeonie BeyerCarolin MeyerDesirée BrösamleAnn-Christin WendelnCollins Osei-SarpongSteffanie HeindlArthur LieszSophia StoeckleinGloria BiecheleAnika FinzeFlorian EckenweberSimon LindnerAxel RomingerPeter BartensteinMichael WillemSabina TahirovicJochen HermsKatharina BuergerMikael SimonsChristian HaassRainer RupprechtMarkus J RiemenschneiderNathalie L AlbertMarc BeyerJonas J NeherLars PaegerJohannes LevinGünter U HöglingerRobert PerneczkySibylle I ZieglerMatthias BrendelPublished in: Molecular neurodegeneration (2024)
Using TSPO-PET imaging of mice with depleted microglia and scRadiotracing in an amyloid model, we provide first evidence that a microglia connectome can be assessed in the mouse brain. Microglia synchronicity is closely associated with cognitive decline in AD and could serve as an independent personalized biomarker for disease progression.