Impaired dental implant osseointegration in rat with streptozotocin-induced diabetes.

Natsumi Saito Risako Mikami Koji Mizutani Kohei TakedaHiromi KominatoDaisuke KidoYuichi Ikeda Prima BuranasinKeita NakagawaShu TakemuraTakeshi Ueno Keiichi Hosaka Takao HanawaTamayuki ShinomuraTakanori Iwata

Published in: Journal of periodontal research (2022)

In diabetes, high-glucose-induced oxidative stress downregulates proliferation and calcification of BMMSCs, impairing osseointegration and leading to implant failure.

Keyphrases

high glucose
endothelial cells
type diabetes
cardiovascular disease
diabetic rats
glycemic control
soft tissue
oxidative stress
high fat diet
hydrogen peroxide
chronic kidney disease
signaling pathway
diabetic nephropathy
skeletal muscle
metabolic syndrome