Therapeutic potency of pharmacological adenosine receptor agonist/antagonist in angiogenesis, current status and perspectives.
Amirhossein BahreyniMajid KhazaeiMajid RajabianMikhail RyzhikovSoodabeh ShahidsalesSeyed Mahdi HassanianPublished in: The Journal of pharmacy and pharmacology (2017)
Depending upon the pharmacological characteristics of adenosine receptor subtypes, adenosine elicits anti- or pro-angiogenic responses in stimulated cells. Inhibition of the stimulatory effect of adenosine signalling on angiogenesis using specific pharmacological adenosine receptor agonist, and antagonist is a potentially novel strategy to suppress angiogenesis in tumours.