Therapeutic potency of pharmacological adenosine receptor agonist/antagonist in angiogenesis, current status and perspectives.

Amirhossein BahreyniMajid KhazaeiMajid RajabianMikhail RyzhikovSoodabeh Shahidsales Seyed Mahdi Hassanian

Published in: The Journal of pharmacy and pharmacology (2017)

Depending upon the pharmacological characteristics of adenosine receptor subtypes, adenosine elicits anti- or pro-angiogenic responses in stimulated cells. Inhibition of the stimulatory effect of adenosine signalling on angiogenesis using specific pharmacological adenosine receptor agonist, and antagonist is a potentially novel strategy to suppress angiogenesis in tumours.

Keyphrases

protein kinase
endothelial cells
vascular endothelial growth factor
current status
induced apoptosis
wound healing
oxidative stress
endoplasmic reticulum stress