Tubal histopathological abnormalities in BRCA1/2 mutation carriers undergoing prophylactic salpingo-oophorectomy: a case-control study.
Federica SinaChiara CassaniChiara ComerioElena De PontiFrancesca ZanelliniMartina Delle MarchetteGaia RoversiMarta JaconiEloisa ArbustiniMario UrtisCristina Dell'OroBenedetta ZambettiCristiana PanigaEleonora AcamporaSerena NegriSara LazzarinStefania CesariArsenio SpinilloJoanne KotsopoulosRobert FruscioPublished in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (2021)
We found that a p53 signature is a frequent finding both in BRCA1/2 mutation carriers and in controls, while pre-invasive and invasive lesions are more frequent in BRCA1/2 mutation carriers. Genetic and clinical characteristics are likely to affect the progression to malignancy.