Preoperative Mutational Analysis of Circulating Tumor Cells (CTCs) and Plasma-cfDNA Provides Complementary Information for Early Prediction of Relapse: A Pilot Study in Early-Stage Non-Small Cell Lung Cancer.
Athina N MarkouD LondraD StergiopoulouI VamvakarisK PotarisI S PaterasAthanasios ΚotsakisVassilis GeorgouliasEvi S LianidouPublished in: Cancers (2023)
Simultaneous mutational analyses of plasma-cfDNA and CTC-derived DNA provided complementary molecular information from the same blood sample and greater diversity in genomic information for cancer treatment and prognosis. The detection of specific mutations in ctDNA and CTCs in patients with early-stage NSCLC before surgery was independently associated with disease recurrence, which represents an important stratification factor for future trials.
Keyphrases
- circulating tumor cells
- circulating tumor
- early stage
- health information
- sentinel lymph node
- small cell lung cancer
- minimally invasive
- patients undergoing
- single molecule
- healthcare
- copy number
- gene expression
- label free
- squamous cell carcinoma
- coronary artery bypass
- social media
- nucleic acid
- locally advanced
- surgical site infection
- genome wide