Pro-inflammatory activation changes intracellular transport of bevacizumab in the retinal pigment epithelium in vitro.

Julia HildebrandtTom KäckenmeisterKatrin WinkelmannPhilipp DörschmannJohann RoiderAlexa Klettner

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2021)

Pro-inflammatory activation of RPE cells with TLR-3 agonist Poly I:C changes the interaction of RPE cells with the anti-VEGF compound bevacizumab, reducing its uptake and transport. On the other hand, bevacizumab might influence pro-inflammatory cytokine release. Our data indicate that inflammation may influence the pharmacokinetic of bevacizumab in the retina.

Keyphrases

induced apoptosis
metastatic colorectal cancer
cell cycle arrest
oxidative stress
immune response
endoplasmic reticulum stress
inflammatory response
toll like receptor
signaling pathway
electronic health record
vascular endothelial growth factor
big data
pi k akt
deep learning
data analysis