COX2 confers bone marrow stromal cells to promoting TNFα/TNFR1β-mediated myeloma cell growth and adhesion.

Chunmei KuangYinghong ZhuYongjun GuanJiliang XiaJian OuyangGuizhu LiuMu HaoJiabin LiuJiaojiao GuoWenxia ZhangXiangling FengXin LiJingyu ZhangXuan WuHang XuGuancheng LiLu XieSongqing FanLugui QiuWen Zhou

Published in: Cellular oncology (Dordrecht) (2021)

Our results indicate that COX2 contributes to BMSC-induced MM proliferation and adhesion by increasing the secretion of PGE2 and TNFα. Targeting COX2 in BMSCs may serve as a potential therapeutic approach of treating MM.

Keyphrases

bone marrow
rheumatoid arthritis
biofilm formation
mesenchymal stem cells
high glucose
signaling pathway
diabetic rats
cancer therapy
drug induced
endothelial cells
staphylococcus aureus
drug delivery
cystic fibrosis
candida albicans
cell adhesion