Parasitological and histological aspects of Holochilus sciureus naturally infected by Schistosoma mansoni.
Nêuton da Silva-SouzaAna Patrícia de Carvalho da SilvaRenata Mondego de OliveiraMaria Gabriela Sampaio LiraRanielly Araújo NogueiraTatiane Aranha da Penha-SilvaSolange de Araújo MeloFábio Henrique Evangelista de AndradeLarissa Sarmento Dos Santos-RibeiroAlcina Vieira de Carvalho NetaAna Lucia Abreu-SilvaPublished in: Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria (2020)
Schistosomiasis is a neglected disease that affects millions of people around the world, being common in the state of Maranhão. A total of 225 rodents of the Holochilus sciureus species from the Western Lowland Maranhão were studied, of which 144 animals (64%) exhibited Schistosoma eggs in their feces samples. Macroscopic lesions characterized as well-defined whitish areas on the liver and spleen surfaces were observed. Histopathological examination revealed multifocal granulomas in the esophagus, liver, spleen, pancreas and duodenum, with structures compatible with Schistosoma mansoni eggs, as well as severe hepatic micro-vacuolar degeneration, multifocal and coalescent, with proliferation of random bile ducts and associated epithelial hyperplasia to areas of fibrosis. Adult forms of the parasite were observed in the blood vessels of the portal space. The lungs exhibited moderate and diffuse interstitial pneumonia with intralesional S. mansoni eggs. In the kidneys, hyaline cylinders were observed in the pelvis and diffuse hemorrhage. In conclusion, H. sciureus displays a pathological picture similar to human being. This rodent plays a role as sentinel in Baixada Maranhense.