Citrullinated histone H3, a marker of extracellular trap formation, is increased in blood of stable asthma patients.

Pawel KucziaJoanna ZukTeresa IwaniecJerzy SojaJerzy DropinskiMarta Malesa-WlodzikLech ZarebaJan G BazanAnetta UndasStanisława Bazan-Socha

Published in: Clinical and translational allergy (2020)

Asthma is characterized by increased circulating H3cit likely related to the enhanced lung ETs formation. Inhibition of ETs might be a therapeutic option in selected asthma phenotypes, such as neutrophilic asthma.

Keyphrases

chronic obstructive pulmonary disease
lung function
allergic rhinitis
end stage renal disease
transcription factor
ejection fraction
chronic kidney disease
newly diagnosed
cystic fibrosis
prognostic factors
peritoneal dialysis