Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency.

Andrew E ArrantAlexandra M NicholsonXiaolai ZhouRosa RademakersErik D Roberson

Published in: Molecular neurodegeneration (2018)

These data do not support the hypothesis that Tmem106b reduction protects against the pathogenic effects of progranulin haploinsufficiency, but do show that Tmem106b reduction normalizes some lysosomal phenotypes in Grn +/- mice.

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