Optimization of β-Lactam Dosing Regimens in Neonatal Infections: Continuous and Extended Administration versus Intermittent Administration.

Emiel LeegwaterLeo WewerinkeAnne M de GrauwMirjam van VeenBert N StormMatthijs D Kruizinga

Published in: Clinical pharmacokinetics (2023)

Continuous infusion after a loading dose leads to a higher PTA compared with continuous, intermittent or prolonged infusion, and therefore has the potential to improve treatment with β-lactam antibiotics in neonates.

Keyphrases

low dose
high intensity
gram negative
risk assessment
replacement therapy
preterm birth